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A new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives

Journal: Iranian Chemical Communication (Vol.3, No. 2)

Publication Date:

Authors : ; ; ; ;

Page : 114-120

Keywords : Thieno[3; 2-e][1; 2; 4]triazolo[4; 3-c]pyrimidines heterocyclization acetic anhydride air oxidation;

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Abstract

A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air oxidation. The products were obtained in high yield with an easy work-up in simple reaction along with the purification of products by non-chromatographic method. This general synthetic procedure can be extended to the preparation of a wide variety of isomeric triazoles using 2-amino thiophene-3-carboxamide bifunctional derivatives.

Last modified: 2019-06-26 14:08:43