ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Guanidine hydrochloride: An efficient catalyst for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives under solvent free conditions

Journal: Iranian Chemical Communication (Vol.5, No. 2)

Publication Date:

Authors : ; ; ;

Page : 227-236

Keywords : 2-Hydrazolyl-4-thiazolidinones; thiosemicarbazide; maleic anhydride; guanidine hydrochloride; solvent free;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

A Highly efficient protocol has been developed for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives installing a one pot three component coupling reaction of an aromatic aldehyde, thiosemicarbazide and maleic anhydride using guanidine hydrochloride as highly inexpensive and environmentally friendly catalyst under solvent free condition at 1200C with good to excellent yields, It offers short reaction time, good to excellent yields and simple and easy workup procedure as compared to the traditional methods of synthesis. The products are characterized by spectroscopic methods like IR and 1H NMR. In the present protocol we reports unsaturated aldehydes first time using guanidine hydrochlori with excellent yields.

Last modified: 2019-06-26 14:20:01