Efficient one-pot synthesis of 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates catalyzed by nano MgO in water
Journal: Iranian Chemical Communication (Vol.6, No. 2)Publication Date: 2018-04-01
Authors : Maryam Sojoudi; Masoud Mokhtary;
Page : 125-133
Keywords : 6-Amino-5-cyano-4H-pyrans; malononitrile; nano MgO; one-pot reaction; water;
Abstract
Water is a versatile solvent in many ways, and in this sense performing organic reactions in this medium is now of great interest. The one-pot reaction of ethyl acetoacetate or benzyl acetoacetate, with benzaldehydes and malononitrile to provide some novel 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates has been performed over nano MgO with high performance in water as a green solvent at 80 °C. The nanocrystalline MgO catalyst was characterized via X-ray diffraction (XRD), transmission electron microscopy (TEM) and BET analysis. This method offers considerable improvements for the synthesis of 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates with concern to the yield of products, facility in operation, and green aspects without using of toxic catalysts and solvents.
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Last modified: 2019-06-26 14:24:08