Photosensitization of coronene–purine hybrids for photodynamic therapy
Journal: Iranian Chemical Communication (Vol.7, No. 4)Publication Date: 2019-07-01
Authors : Amir Hossein Rasouli Amirabadi; Mahmoud Mirzaei;
Page : 398-404
Keywords : photodynamic therapy; photosensitizer; coronene; adenine; guanine;
Abstract
Photosensitization properties of coronene-purine (Cor-P) hybrids for photodynamic therapy (PDT) have been investigated in this work. Eight hybrid Cor-P models have been designed by the additional of adenine (A) and guanine (G) nucleobase to Cor species. The evaluated absorption and emission energies indicated that the singular models are not good at all for PDT process whereas their hybrid models are very much useful for the purpose. Although the Cor-A models are very much better for visible region, but the Cor-G models could be also used in the near-infrared region. The main point of these materials is to generate singlet molecular oxygen, in which all investigated Cor-P hybrids could supply the required energy for triplet to singlet conversion of molecular oxygen. This work has been done based on the advantage of quantum computation for solving the problems in living systems.
Other Latest Articles
- Multi-component synthesis of spiro[indoline-3,4'-pyrrolo[3,4-c]pyrazoles] using Zn(BDC) metal-organic frameworks as a green and efficient catalyst
- A computational molecular approach on chitosan vehicle for metformin
- Synthesis and characterization of MCM-41@L-arginine@Pd(0) and its excellent catalytic activity as recyclable heterogeneous catalyst for Suzuki-Miyaura cross-coupling reaction
- An investigation on absorption properties of exfoliated graphite for oil spill from Caspian Sea water
- Adsorption of proline amino acid on the surface of fullerene (C20) and boron nitride cage (B12N12): A comprehensive DFT study
Last modified: 2019-06-26 14:31:28