ANTIMICROBIAL, TOXICOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THE COMPLEX CO(II) WITH THIOSEMICARBAZONE OF GLYOXYLIC ACID

The complex Co(II) with thiosemicarbazone of glyoxylic acid Co(HGAT)2H2O was synthesized, and added into the hemolymph tissue of model larvae of Galleria mellonella L and some biochemical parameters and changes of metabolic enzymes activity were studied. For a research used the enzymes Aspartate aminotransferase, Alanine Aminotransferase, Lactate dehydrogenase, Creatine Kinase and Gamma-glutamyltransferase. The first three of them on results of experiments present the greatest interest, so they are chosen for research.. Measurements were taken through 2, 4, 6 and 8. It was revealed that the introduction of the complex synthesized by us to into the first two enzymes increases their bioindicator activity. Introduction of the complex to Lactate dehydrogenase increases activity of the last with 30 ± 2.76 to 131.25 ± 3.10 in 8 hours. The effective results we obtained convinces us of the need to use them to study metal complexes of various structures and mechanisms of influence on the organism and also for fight with wreckers insects at the minimum damage to the environment. Also results of antibacterial and antifungal properties both a ligand, and complex are described