Features of Reduction of Th1, Th2 Lymphocytes Functions After Intoxication of Various Toxic Chemicals| Biomed Grid

Experiments on random-bred albino rats showed that organophosphorus compound (malathion) acute intoxication (0.5 LD50) in the greater degree reduces function of Th1 lymphocytes and bound with them of delayed-type hypersensitivity (DTH) reaction and production IFNγ, in comparison with function of Th2 lymphocytes and synthesis of IL-4 by them; the opposite effect is characteristic for methanol (0.5 LD50; decreases Th2-lymphocytes function (IgG and IL-4 production) to a greater extent); acetonitrile and trichloromethane acute intoxications (0.5 LD50) invokes a reduction of functions of Th1 and Th2 lymphocytes and production of cytokines by them (IFNγ and IL-4) equally