ANTIPYRETIC ACTIVITY OF BLUMEA LACERA LEAVES IN ALBINO RATS

The present study was carried out to determine the antipyretic activity of the methanolic extract of Blumea lacera leaves (BLE) on albino rats. Acute toxicity study of BLE was performed by limit test as per OECD guideline. Antipyretic activity was studied by inducing pyrexia with Brewer's yeast. Acute oral LD50 of BLE in female rats was more than 2000 mg/kg. Three ascending doses of 100 (1/20 LD50), 200 (1/10 LD50) and 400 mg/kg (1/5 LD50) were selected for studying the antipyretic activity of BLE in rats. BLE at dose rates of 200 and 400 mg/kg reduced brewer's yeast induced pyrexia in rats suggesting antipyretic effect of BLE.