Effects of chlorpheniramine (histamine H1 receptor antagonist) on food and water intake in broiler chickens in hunger and satiety

The role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of chlorpheniramine as histamine H1-receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male Ross broiler chicks reared in groups of four weeks, 16 samples (control and test) were then injected with 0.5 ml chlorpheniramine (40 mg per kg of body weight) intraperitoneally, feed intake and water per chick at intervals of 15, 30, 45, 60, 90 min and2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 21, 23 h after injection and the controls weight was recorded. The results showed that chlorpheniramine in satiety after injection caused a significant decrease (p < 0.0001) in feed intake compared with the control group. Chlorpheniramine injection in starvation mode after injection induced a significant decrease (p < 0.0001) in feed intake compared with the control group. Satiety in a state of chlorpheniramine in180, 240,300, 360, 420, 480, 540, 600, 660, 720 min after injection (p < 0.0001) caused a significant reduction in water use. Chlorpheniramine injection, at 180, 240, 300, 360, 420, 480, 540, 600 min after injection (p < 0.05) caused a significant reduction in water consumption.