APHRODISIAC DRUGS FOR WOMEN AND ITS CORRELATION WITH SEROTONIN

Effect of PGE1 (0.4 mg/kg i p ) and Drugs affecting serotonin and Prostaglandin metabolism including aphrodisiac plants on the serotonin level in rat uterus in estrus, and pregnant state were taken up in the present study. Female aphrodisiac an upcoming branch became a thrust area after the discovery of Sildenfil. Some known aphrodisiac plants and natural products showed to increase uterine 5-HT level. The 5-HT response in rat's uterus is different in estrus and non-estrus state .The uterine 5-HT content increase three fold in estrus in comparison to non-estrus state. Drugs like l-tryptophan increase 5-HT synthesis and projected 5-HT concentration in uterine tissue. Monoamine oxidase inhibitor (MAOI) pargyline also increased uterine tissue 5-HT. PGE1 like brain and intestine increased in uterine 5-HT. Indomethacin and diclofenac sodium known to block prostaglandin synthesis by inhibiting prostaglandin synthetase like pCPA reduced the 5-HT content. In pregnant uterus 5-HT content increased while Prostaglandin treatment both in estrus and nonestrus condition also increased 5-HT content more than three fold. Herbs with known aphrodisiac activity contain 5-HT showed significant increase in uterine 5-HT content significantly. The results such obtained show a silvelining in future study of these drugs for therapeutic use.