Mapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels
Journal: International Journal of Advanced Biological and Biomedical Research (Vol.2, No. 5)Publication Date: 2014-05-01
Authors : A.A. Khabiri; M. Tahmoorespur; Nassiri; M.H. Sekhavati;
Page : 1726-1733
Keywords : κ-casein; bioinformatics analysis; Camels; Transcription factors;
Abstract
κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription factors binding sites (TFBSs). We determined the 5’ region for Iranian Dromedaries and bactrianus camel κ-casein gene. We also determine their regulatory TFBSs regions. This region contained 14 potential TFBSs The four of them C/EBP-α, Oct1, MGF/STAT5 and TPB have almost perfectly conserved.
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