Anticonvulsant Activity of Aqueous Root Extract of Annona Senegalensis Pers
Journal: International Journal of Advanced Biological and Biomedical Research (Vol.2, No. 8)Publication Date: 2014-08-01
Authors : S.A. Igwe; N.N. Nwobodo;
Page : 2441-2447
Keywords : Annona senegalenesis pers; Anticonvulsant; Clonic spasm; Ethnomedicine; Febrile convulsion;
Abstract
Objective: Annona senegalenesis Pers is a sprawling shrub belonging to the family Annonaceae, and is mainly used in ethnomedicine. The use of decoction of A. senegalenesis is very prominent in the management of various conditions ranging from bacterial infection, worm infestation, snake bites, pyrexia and febrile convulsion in folk medicine. Methods: The investigation on anticonvulsant activities of A. senegalenesis was undertaken using animal models with a view to elucidating its mechanism of action Results: Results revealed that the aqueous extract of the root of A. senegalenesis was safe at high doses (LD50 954.99±2.86 mg/kg body weight), protected drug–induced convulsion in mice, prevented electroshock in mice, being more effective against generalized than partial seizures and prolonging drug-induced sleep in mice. We conclude that the roots of A. senegalenesis have definite anticonvulsant activity and there is valid pharmacological basis for employing same for this purpose by the local people.
Other Latest Articles
- Effect of Manure Application on Reduced Nitrogen Fertilizer Consumptionin Potato Cv.Agria
- Topoisomerase Inhibitors and Types of Them
- Water Quality Evaluation of Torghabeh River of Mashhad Using Combination of NSFWQI Index and Geographic Information System
- Molecular Typing by Polymerase Chain Reaction Sequence Specific Primers (PCR- SSP) of Human Leukocyte Class I and Class II Alleles in a Sample of Iraqi Visceral Leishmaniasis Patients
- Bioaccumulation and Histopathological Alterations in Liver Caused by Endosulfan Toxicity in Oreochromis Niloticus
Last modified: 2019-07-05 05:05:28