IN SITU BIO-ACTIVATION AND INACTIVATION MECHANISM IN PSORALEA CORYLIFOLIA EXTRACT AND ASSOCIATED SAFETY FOR PSORIASIS AND VITILIGO

The present study deals with the in situ bio-activation and inactivation mechanism of Psoralea corylifolia extract and its associated safety. The natural extracts of Psoralea corylifolia showed photosensitivity only instantaneously whereas after 30 minutes no photosensitivity was observed. The possible dermal reaction with various other biomolecules of Psoralea corylifolia extract may be ‘switching off' the activity of Trioxsalen and Methoxsalen. The programmed inactivation of photosensitivity of Psoralea corylifolia extract clearly highlights its efficacy and safety over synthetic derivatives of Psoralen- Trioxsalen and Methoxsalen. TLC, Spectrogram, cyanotype paper based photo reaction and volunteer based study were conducted to establish the above scientific fact. Details are presented in the paper.