A COMPARATIVE STUDY OF TOCOLYSIS WITH ATOSIBAN VS PROGESTERONE IN MANAGEMENT OF PRETERM LABOR

OBJECTIVE A cross sectional prospective study in Bint Al-Huda Teaching Hospital extended from 1st of October 2017 to 15th of February 2018. The study was undertaken with the aims of determining the efficacy of atosiban in management of preterm labor and comparison atosiban with progesterone in prolongation of pregnancy and postpone preterm labor. MATERIALS & METHODS In the study 130 pregnant women presenting with threatened preterm labor between 24 – 34 wks of gestation, who were assigned to receive tocolysis with either atosiban ( n= 65 ) or progesterone ( n= 65 ) RESULTS The effectiveness of tocolysis was determined by the duration of pregnancy prolongation for more than 48 hrs, 7 days or 14 days. The primary outcome was the rate of pregnancy prolongation for 48 hrs. Tocolysis failed in 8 women in atosiban group while failed in 20 women in progesterone group, 12 women delivered after 48 hrs in atosiban group while 23 women in progesterone group, 20 women delivered after 7 days in atosiban group while 12 women in progesterone group, 25 women delivered after 14 days in atosiban group while 10 women in progesterone group . So there was a significant association between the treatment strategies in form of atosiban or progesterone with outcome of delivery, where P value ˂ 0.05. CONCLUSIONS The atosiban more effective than progesterone in prolongation of pregnancy in threatening preterm labor .