DEVELOPMENT AND VALIDATION OF UV- VISIBLE SPECTROPHOTOMETER METHOD FOR ESTIMATION OF RIVASTIGMINE IN HUMAN PLASMA

The main purpose of this study was to develop a simple precise, rapid and accurate uv-visible spectrophotometric method for determination of rivastigmine in spiked human plasma by extracting the Rivastimine from spiked human plasma using methanol after extraction it was scanned between 200-400nm by using uv detector and its absorbance maxima was found to be 270nm.the calibration curve was linear in the range of 6-15ppm .the recovery and assay studies of rivastigmine were within 99 to 102% indicating that the proposed method can be quality control analysis of rivastigmine.