Synthesis of icosadeuterio-benzopinacol (benzopinacol-d20)
Journal: Journal of Medicinal and Chemical Sciences (Vol.3, No. 1)Publication Date: 2020-01-01
Authors : Steeve M. Adjibodéa; Urbain C. Kasséhin; Fernand A. Gbaguidi; Jacques H. Poupaert;
Page : 35-40
Keywords : benzopinacol-d20; benzophenone-d10; dimerization; photo-reductive;
Abstract
This work reports on synthesis of high yield (92%) of isosadeuterio-benzopinacol (benzopinacol-d20) via photo-reductive dimerization of benzophenone-d10. The latter compound was obtained using an improved method to achieve a material with high isotopic purity (> 99%). This material can be served for calibration of Mass spectrometric assays. In this study, it was also observed that benzophenone-d10 reacts faster than its natural abundance counterpart. However, elucidating the origin of this phenomenon will require additional work.
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