GC-MS BASED METABOLIC PROFILE OF BRAIN TISSUE IN COMMON CARP FOLLOWING ACUTE EXPOSURE TO CYPERMETHRIN

In the current study, the GC-MS metabolomics analysis was employed to explain the neurotoxic effect of cypermethrin on the metabolic profile in the brain of carp fish. The carps exposed to two concentrations of cypermethrin (0.1 and 1 ?g/L) for 24 and 96 hours. The levels of glutamate, tryptophan, tyrosine, glutamine and histidine showed marked increase, while levels of GABA and glycine were decreased compared to control group. Additionally, cypermethrin significantly reduced the level of glucose at 24 h suggesting a disruption in energy production with subsequent usage of lactate as an energy source. Collectively, the present work is the first that proposes a possible mechanism of cypermethrin neurotoxicity in carp fish and reflects the risk of cypermethrin existence in an aquatic environment.