Peculiarities of immunore resistance changes in the experiment of induced peritonitis in animals of different ages
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.37, No. 37)Publication Date: 2019.08.12
Authors : Marina Ivanenko Olena Klimova Serhii Sherstiuk Svitlana Nakonechna;
Page : 5-11
Keywords : ;
Abstract
The article describes some peculiarities of changes in the indicators of adaptive humoral immunity, levels of immunoglobulin A and circulating immune complexes, phagocytic activity of neutrophils and the disruption of enzymes activity, which provide the phagocyte function in the NST test on the model of induced peritonitis in animals of different ages. The results of the study indicate certain violation of the primary cellular and secondary humoral immunity during the aging of the body and decrease in the adaptive responses of the immune system during inflammation due to an increase in antigenic effects. The levels of immunoglobulin A in the blood serum of 3 and 22-month-old rats with the inflammation model were reduced in comparison with this index in control group animals. The content of the CIC in the rats blood serum of both age groups was significantly higher in comparison with the control group. All the studied indices of neutrophils phagocytic activity in the 22-month-old animals with the inflammation model were lower than in the control rats of this age. In the 3-month-old rats with the inflammation model, the index of phagocytosis completeness was significantly lower in comparison with the control group. The reduction in the reserve capacity of phagocytic cells was higher in the 22-month-old animals. An increase in the neutrophils metabolic activity and a decrease in their metabolic reserve in 3 and 22-month-old rats with the inflammation model were revealed in comparison with the parameters of the control groups.
Other Latest Articles
- PATTERN-RECOGNIZING RECEPTORS AND THE INNATE IMMUNE RESPONSE TO VIRAL INFECTION
- ENDOGENOUS RETROVIRUSES AS GENETIC MODULES THAT SHAPE THE GENOME REGULATORY NETWORKS DURING EVOLUTION
- AUTOLOGOUS PLATELET‐RICH PLASMA: A REVIEW OF SCIENTIFIC ARTICLES ON THE STUDY OF EFFICIENCY IN TREATMENT OF ANDROGENETIC ALOPECIA IN MEN AND WOMEN
- ABDOMINAL COMPARTMENT SYNDROME IN BURN PATIENTS
- ANGINA PECTORIS AND MYOCARDIAL ISCHEMIA IN THE ABSENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE: CLINICAL CASE
Last modified: 2019-08-12 19:29:03