Formulation and Evaluation of Fast Dissolving Tablets of Loratadine Solid Dispersion Using Super disintegrantsJournal: Indian Drugs (Vol.56, No. 07)
Publication Date: 2019-07-27
Authors : Kumar S.; Kumar J. V.and Singhal P.;
Page : 88-91
Keywords : ;
Loratadine is a water-insoluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of Loratadine using super disintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. The SD's of the drug were prepared by melt dispersion technique using polyethylene glycol (PEG) 6000 in deferent ratios of 1 : 2.5, 1 : 5 and 1 : 7.5. The prepared SD formulations were characterized for equilibrium solubility, Fourier Transform Infrared spectroscopy (FTIR) and in vitro dissolution study. The batch containing SD formulation in loratadine showed fastest dissolution (99.87% drug release in 60 min). In this study, fast dissolving tablets were prepared by direct compression method using Croscarmellose sodium, sodium starch glycolate and polyplasdone XL as the super disintegrants. Effect of various super disintegrants on dissolution behavior of tablets was evaluated in phosphate buffer pH 6.8.
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