Functional Cardiac Parameters Calculated in Early Diabetes using 64 Slice CT Scanner

Aims: The study aimed at evaluation of the feasibility of cardiac MDCT for assessment of diastolic function in asymptomatic diabetic patients as compared to echocardiography and to study the intermodality correlation of observed findings. Methods: A total of 15 normotensive, non-coronary artery disease (CAD) diabetic patients and 15 age-matched asymptomatic controls were included in the study. All of them underwent 2D echocardiography with Tissue Doppler Imaging and MDCT. LV volume and LV length were calculated and were plotted against time. Further, early (E) and late (A) transmitral peak velocities (cm/s) and peak mitral septal tissue velocity (Ea; cm/s) were derived for the assessment of diastolic dysfunction and LV filling pressure (E/Ea) was also estimated. Results: A total of 73.3% (11 out of 15) patients showed diastolic dysfunction by both MDCT and echocardiography. Good correlation was observed between cardiac MDCT and 2D echocardiography for assessment of E (r=0.992; p<0.001), A (r=0.974, p<0.001), E/A (r=0.979; p<0.01), Ea (r=0.977; p<0.001), and E/Ea (r=0.994; p<0.001). Conclusions: Our study showed good correlation between MDCT and echocardiography for assessment of diastolic dysfunction in asymptomatic normotensive diabetic patients. Hence, cardiac MDCT can be used a problem solving tool along with echocardiography for assessing LV diastolic function. It does not replace echocardiography but rather extends its capabilities and offers advantages in various clinical settings.