Long-term Survival in Two Dogs with Intracranial Meningioma Treated with Lomustina and Prednisone

Meningioma is a benign tumor that has origin in the meninges. Histologically, the tumor cells are characterized by the formation of cytoplasmic fibrils, collagen and desmosomes. Due to poor prognosis of patients, this study aimed to report the diagnostic and therapeutic approach of two intracranial meningioma tumors in dogs. A 6-years-old, female Boxer dog and an 11-years-old, female Poodle dog were presented at the Internal Medicine Service at the Veterinary Hospital with neurological signs. A computed tomography (CT) scan with an intravenous contrast was performed in both subjects and a neoformation was found in the cerebellum and optic quiasm, respectively. After diagnosis, the chemotherapeutic protocol based on Lomustine (60 mg/m²) every 21 days, orally and 1 mg/kg of prednisone every 24 hours throughout the treatment.After establishment of the therapeutic protocol, the animals showed remission of clinical signs. The subject 1was kept under treatment for 180 days and after this period the animal died and necropsy was performedshowing a mass measuring 2x2x2 cm in the cerebellum. The subject 2 was kept under treatment for 120 days and after this period the animal was submitted to another CT scan where was noticed the enlargement of the neoplasia. The subject had 240 days of therapeutic control. Chemotherapy with lomustine associated with prednisone was effective in remission of clinical signs and patient stabilization.