Activity of Methanol Extract of Leptadenia HastataLeaves in Alcohol-Induced Liver Injury | Biomed Grid

This study investigated the hepatoprotective effects of methanol leaf extract of Leptadenia hastata (MELH) in chronic alcohol-induced liver injury in rats. The animals were given 5ml/kg ethanol then treated with the extract (250 and 500 mg/kg). This treatment was done orally and daily for 5 weeks. Twenty- four (24) hours after the last treatment, the rats were sacrificed under anaesthesia and blood samples were collected for the assay of aspartate amino transferase (AST) of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) was also assayed in the serum. The levels of other biochemical markers of organ damage such as total cholesterol, triglycerides, total bilirubin and total protein were determined. The liver was excised for relative organ weight estimation as well as histological examination. The extract at both doses produced significant (P<0.05) decrease in the serum activities of ALT, AST, ALP, serum levels of total cholesterol; triglycerides and total bilirubin as well as significant (P<0.05) increase in serum concentration of total protein and albumin in comparison with the negative control that received only alcohol. The histopathological result showed protection in the extract- treated groups when compared with the group that received alcohol alone. It was concluded that methanol leaf extract of Leptadenia hastata showed promising hepato-protection activity in rats with alcohol-induced liver damage. Thus, the plant could be useful in the management of liver diseases.