Antifungals therapeutic failure: Causes beyond steroid abuse

Severity of fungal infection can range from asymptomatic- mild mucocutaneous infections to potentially life threatening systemic disease. Socioeconomic and geoecologic characteristics and increasing number of at risk population are the main determinants of variation in incidence & prevalence of fungal infections. A variety of antifungal drugs are available, but the emerging issue of resistance is of paramount importance. Major factors implicated in Antifungal therapeutic failures and rising incidence of recurrent & relapse include overcrowding, poor hygienic condition, hot & humid climate, self medication, inappropriate and incomplete treatment, undiagnosed uncontrolled diabetes, malnutrition and obviously the issue of rampant steroid abuse.