Comparative study of hematological parameters in newly diagnosed tuberculosis patient’s pre-att & after intensive phase of ATT

Introduction: Tuberculosis is a highly prevalent chronic infectious disease. TB exerts various hematologic effects & hematological abnormalities. Anti-Tuberculosis treatment has its own spectrum of effects on TB patients. This study aimed to study & compare various hematological parameters in newly diagnosed TB patients before ATT & to evaluate after the intensive phase ATT in same patient. Materials and Methods: A total of 40 newly diagnosed cases of TB were randomly selected. Under aseptic precautions, 2.5 ml of blood collected from patients in EDTA vacutainers & the following hematological parameters were analysed – HB%, TLC, DC, PC, MCV, MCHC, PCV and ESR. The same patients were put on 2 months of intensive phase of ATT. After completion of ATT, the hematological parameters of each patient were analysed. PreATT and after ATT the parameters were compared and analyzed with suitable statistics. Results: There was significant post treatment improvements in Hb%(Pre ATT-10g/dl & post ATT 11.8g/dl), RBC count (Pre ATT-4.8 millions/cumm & Post ATT-4.85 millions/cumm), PCV (Pre ATT-38% & Post ATT-40%), Total leucocyte count (Pre ATT-10,295cells/cumm & post ATT- 9,500 cells /cumm), Neutrophils (Pre-ATT-73% & post ATT-63%) and Lymphocytes (PRE-ATT - 20% & post ATT-30%) and ESR (PreATT 79mm/hr & post ATT 54mm/hr). The present study showed that, there was a significant statistical difference in HB%, TLC, DC, Platelets & ESR values. Conclusion: Hematological parameters can be a guide to assess the improvement of TB patients after ATT which indirectly speaks about the improvement in patients.