Histopathological study of non-neoplastic and neoplastic lesions of salivary gland

Introduction: Salivary gland lesions represent clinical and morphological diversity, which is a difficult task for histopathological interpretation. Classification of salivary glands lesions into non-neoplastic and neoplastic (benign and malignant tumors) is essentially based on histopathological aspect, which is important for management and predicting its prognosis. Aims and Objectives: To study histomorphological (gross and microscopic) aspect of Salivary gland lesions. To classify salivary gland lesions for therapeutic implication. To study the different epidemiological pattern with particular references to age, gender, site and its incidence. To compare and observe the results of this study with other studies Materials and Methods: This is a retrospective study done at Pathology Department, GMERS Medical College and Hospital, Sola, Ahmedabad. The specimens were fixed in 10% formalin, processed by paraffin embedding, stained with H & E and examined microscopically. Results: Out of 66 cases, 22(33%) cases are non-neoplastic and 44(67%) cases are neoplastic. Among 44 neoplastic lesions, 42(95%) cases are benign and 02(5%) cases are malignant. Parotid gland is the most common and well known site for the all salivary glands lesions. Male female ratio was 3.4:1. The mean age found was 39.5 years with age scope of 3 to 72 years. Chronic sialadenitis is the most common non-neoplastic lesion. Most common benign tumor of salivary glands is pleomorphic adenoma followed by Warthin's tumor. The mucoepidermoid carcinoma was only recognized malignant tumor followed by undifferentiated malignant tumor. Conclusion: Owing to complex features exhibited by salivary gland lesions histopathological examination is the mainstay for final diagnosis and categorization for treatment and prognosis.