Effect of Ethanolic Seed Extract of Cola lepidota on the Lipid Profile of High Fat fed Albino Wistar Rats

Female albino wistar rats (n=54) weighing 80-90 g at 6 weeks (42 days) of age were used for this study. Nine experimental treatments involving the random distribution of six (6) rats in each group were carried out. The serum lipid profile of the rats revealed that group 2 (negative control) had significantly high serum TCH, TG, LDL-C and VLDL-C and very low serum HDL-C (p ≤ 0.05) when compared with group 1 (control) while groups 3, 4, 5, 7, 8 and 9 had reduced serum TCH, TG, LDL-C and VLDL-C when compared with groups 1 and 2. The latter groups (i.e., groups 3, 4, 5, 7, 8, and 9) maintained elevated serum HDL-C concentrations when compared with groups 1 and 2. Group 6 had same TCH, TG, and VLDL-C concentrations with group 1 (p>0.05). Aim: To investigation the effect of Cola lepidota seeds on the serum lipid profile of high fat fed albino Wistar rats. Conclusion: Diets high in fat tend to promote overweight, obesity and other fat induced conditions, therefore, inhibiting digestion and absorption of dietary fats becomes a logical remedy to either prevent or ameliorate such conditions. Results have shown that Cola lepidota seeds possess hypolipidaemic and anti-atherosclerotic activities, hence, become good repository for new drug discovery.