THYROID STIMULATORY HORMONE (TSH) REFERENCE RANGES IN THE NORMAL PREGNANT WOMEN OF LUCKNOW

Maternal hypothyroidism is known to be associated with adverse perinatal outcomes. This study was done to evaluate the normal reference range of TSH in pregnant women. 483 pregnant women on their first visit to Obstetrics OPD in Era's Lucknow Medical College and hospital were tested for TSH and TPO antibody using ELISA method. 25 out of 483 were positive for TPO Antibody. Of the remaining 458 patients, 142 were in first trimester, 222 were in second trimester and 94 were in third trimester. The TSH values ranged from 0.043 mIU/L to 10.1 mIU/L (mean = 2.34 mIU/L). The reference range of TSH values in all the trimesters are, 0.35 to 5.82(1st trimester), 0.28 to 5.82(2nd trimester) and 0.11 to 6.8(3rd trimester). The reference range of TSH values among the normal pregnant women of Lucknow and its surrounding areas were found to be higher than those recommended by the test kit.