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METHOTREXATE INDUCED STEVENS JOHNSON SYNDROME: A RARE CASE REPORT

Journal: Era's Journal of Medical Research (Vol.05, No. 02)

Publication Date:

Authors : ;

Page : 164-196

Keywords : Methotrexate; Stevens-Johnson syndrome; Rheumatoid arthritis; Adverse Drug Reaction.;

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Abstract

Methotrexate (MTX) is a folic acid antagonist with cytotoxic and immunosuppressant activity andwith potent antirheumatic action. It is commonly a first choice Disease modifying antirheumatic drug (DMARD). There were some spurious reports of Adverse Drug Reaction (ADR) by this drug. Here we report a rare occurrence of Stevens-Johnson syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) after the use of Methotrexate. Naranjo score for this adverse drug event was six, thereby making it a probable ADR. Symptomatic management of the patient was done and the offending drug was withdrawn. We are presenting this case to highlight the serious adverse reactions possible from a routinely prescribeddrug.

Last modified: 2019-08-28 19:19:33