METHOTREXATE INDUCED STEVENS JOHNSON SYNDROME: A RARE CASE REPORT
Journal: Era's Journal of Medical Research (Vol.05, No. 02)Publication Date: 2019-12-30
Authors : Surabhi Arora Afroz Abidi Fariha Fatima Roohana Hasan Darakhshan Rizvi Anupriya Thadani;
Page : 164-196
Keywords : Methotrexate; Stevens-Johnson syndrome; Rheumatoid arthritis; Adverse Drug Reaction.;
Abstract
Methotrexate (MTX) is a folic acid antagonist with cytotoxic and immunosuppressant activity andwith potent antirheumatic action. It is commonly a first choice Disease modifying antirheumatic drug (DMARD). There were some spurious reports of Adverse Drug Reaction (ADR) by this drug. Here we report a rare occurrence of Stevens-Johnson syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) after the use of Methotrexate. Naranjo score for this adverse drug event was six, thereby making it a probable ADR. Symptomatic management of the patient was done and the offending drug was withdrawn. We are presenting this case to highlight the serious adverse reactions possible from a routinely prescribeddrug.
Other Latest Articles
- INTRACYSTIC BLOOD MIMICKING RECURRENT EPIDERMOID OF CONUSMEDULLARIS: A CASE REPORT
- INTRAARTICULAR INVOLVEMENT BY SYNOVIAL SARCOMA: FIRST DIAGNOSED ON SYNOVIAL FLUID ASPIRATION
- GOLDENHAR SYNDROME: A CASE REPORT
- A CASE OF PARTHENIUM DERMATITS IN A MIDDLE AGED FEMALE
- A CASE OF CHEMICAL LEUKODERMA EFFECTIVELY TREATED WITH PUNCH GRAFT SURGERY
Last modified: 2019-08-28 19:19:33