Diurnal variations in central corneal thickness in glaucoma suspects

Aim: To analyse 24 hour variations of central corneal thickness in glaucoma suspects. Materials and Methods: 130 glaucoma suspects were hospitalised and underwent circadian evaluations. Total 6 readings of CCT were recorded over a 24-hour period: Immediately after waking up, 8 am, 11 am, 2 pm, 5 pm, & 8 pm. CCT was measured using an ultrasonic pachymeter. Results: Mean CCT measurement at each time point: Immediate after wake up: 549.21 um; 08 AM: 548.97 um; 11 AM: 545.82 um; 2 PM: 544.41 um; 5 PM: 544.34 um; 8 PM: 543.65 um. The mean CCT was highest just after wake up with a slight decline throughout the day without any statistical significance in both groups (p>0.05). Conclusion: The mean CCT was found to be highest just after wake up in the right eye and at 08:00 AM in left eye with steady decline throughout the day with statistically significance. The average variation in CCT was less than 1.92% in patients with suspected glaucoma from wake up to 8:00 pm.