Comparative study of glycoproteins in normal individuals and in patients with hypothyroidism and hyperthyroidism

Aim: the present study was carried out to compare the glycoproteins in normal individuals and in patients with hypothyroidism and hyperthyroidism. Materials and Methods: This study was carried out at Meenakshi Medical College & Research Institute on total 90 individuals, 30 hypothyroid patients, 30 hyperthyroid patients and 30 normal individuals were taken as controls. Each group consisted of both sexes and the participants were between the ages of 25 to 50 years. Various parameters like protein bound fucose, hexose, hexosamine, sialic acid and thyroid function test which include ft3, ft4 and TSH were measured in all the 90 individuals. The data was collected and analyzed. Result: Potein bound hexose, sialic acid, fucose and hexosamine decreased in hypothyroid patients when compared to normal individuals, whereas in patients with hyperthyroidism only protein bound hexose and fucose levels increased significantly whereas sialic acid, hexose were decreased when compared to normal individuals. Conclusion: Serum Glycoproteins can be additional markers to ft3, ft4 and TSH and aid in diagnosis and management of thyroid disorders.