Gender specific utility of lipid ratios and its correlation with systemic inflammation in acute myocardial infarction (AMI) patients with type 2 diabetes mellitus – A hospital based study

Objective: To evaluate Gender specific alterations in the levels of serum lipid profile parameters Total Cholesterol (TC), Triglycerides (TG), Low density lipoprotein Cholesterol (LDL-C), High density lipoprotein Cholesterol (HDL-C), non-HDL-C (TC-HDL-C), lipid ratios [TC/HDL, TG/HDL, LDL/HDL, non HDL/HDL, LDL/non HDL], hs-CRP and uric acid in male and female Diabetic patients with Acute Myocardial Infarction(AMI) compared to male and female Diabetic patient controls, and to correlate the serum lipid ratios with serum hs-CRP and uric acid levels among male and female Type 2 DM patients with AMI. Materials and Methods: Blood samples collected after admission from thirty male and thirty female Type 2 DM with AMI, and from thirty male and thirty female Type 2 DM patients with no previous history of coronary heart disease as controls, the samples were analyzed for levels of serum lipid profile, hs CRP and uric acid. Results: There was a significantly high TG/HDL ratio in males diabetic patients p<0> Conclusion: A higher level of dyslipidemia in female diabetic patients with AMI compared to male diabetic patients with AMI necessitates the need to initiate a more aggressive lipid management strategy for women with diabetes. Estimating the serum hs CRP levels as independent parameter may serve as predictor of risk of AMI irrespective of their gender during routine follow up of diabetic patients.