Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease

Introduction: Oxidative stress plays an important role in the progression of atherosclerosis, it is the principal cause for coronary artery disease (CAD). Lipid peroxidation product Malondialdehyde (MDA) is an index of oxidative stress. To assess the oxidative stress, MDA and total antioxidant capacity (TAC) are estimated. Body fat distribution was assessed by obesity and blood lipids, which in turn was measured by Body mass index (BMI) and waist circumference (WC). Cystatin C was measured as an emerging cardio vascular risk factor. Materials and Methods: Study consists of two groups, 145 subjects diagnosed with CAD are included in study group and 66 age and sex matched subjects (non CAD) are included in control group. Results: In this study, Cystatin C is highly significant observed in CAD cases than controls. BMI and WC are not significantly increased; whereas significant increase in mean MDA and decrease in mean TAC levels. Conclusion: Oxidative stress is markedly observed in CAD cases, due to toxic effects of ROS. Increase in Cystatin C levels significantly correlated with WC in middle aged individuals.