ASSESSMENT OF THE RELATIONSHIP BETWEEN THE MONITORING RESULTS OF PATIENTS WITH VIRAL HEPATITIS-RELATED HEPATOCELLULAR CARCINOMA AND TYPE 2 DIABETES MELLITUS

Background:Among the etiological factors of hepatocellular carcinoma (HCC), which is the most frequently encountered cause of primary liver cancers, viral hepatitis cases are at the top. The relationship between glucose anomalies and HCC development in especially patients with viral hepatitis C and B infections is still a topic of curiosity. In this study, we aimed to assess the potential relationship between the chronic hepatitis C and B infections (HBV and HCV) in monitoring of HCC patients and type 2 diabetes mellitus (DM) comorbidity. Material and Method:A total of consecutive 51 HCC patients with a mean age of 69.98?11.92 years were enrolled in this study. The Barcelona-Clinic Liver Cancer (BCLC) criteria were used for staging the patients with HCC. HBsAgseroprevalence with the Anti-HCV antibody was studied with the ELISA method. The patients were grouped based on presence of diabetes, and the relationships between disease stages and viral etiological factors were statistically analyzed. Results:In patients with HCC, DM prevalence was 41.2%. 55.6% of Chronic hepatitis C patients and only 33.3% of chronic hepatitis B patients had diagnoses of DM (p=0.107). According to the BCLC stages in the patients, the DM rates at A, B, and C were 40%, 45.5% and 50% respectively (p<0.05). Conclusion:Blood sugar regulation in chronic viral hepatitis patients with DM may contribute to reduction of HCC risk.