Clinico-pathological evaluation of non-neoplastic and neoplastic skin lesions: A study of 100 cases

Introduction: Skin is the largest organ among all the organs of the body. The clinical manifestations of diseases of skin are vary in nature both in clinical presentations and behavior. It is necessary to cross talk between pathologist and dermatologist for better management of patients. Histopathological examination plays a significant role and the gold standard in providing accurate diagnosis for a variety of skin lesions. Objective: 1. To evaluate histopathology as an ideal diagnostic method for vesiculobullous (non–neoplastic) and neoplastic (tumourous) skin lesions. 2. To establish the correlation between the microscopic pathological findings of various skin lesions with the presenting clinical features. Materials and Methods: 100 patients of skin diseases were included for the study. Punch, excisional or incisional biopsy techniques were used to get the tissues. The tissue was obtained for detailed histopathological examination. The histological sections were stained with hematoxylin and eosin stains and histochemical stains were used as supplementary diagnostic tool. Results: Out of 100 patients, 54% had vesiculobullous lesions, 22% granulomatous morphology and 24% were neoplastic. Epidermoid cysts included in benign neoplasm category and accounted for 37.5% of neoplasms. Squamous cell carcinoma was the most common malignant tumor (52.8%). Conclusion: Histopathological study of skin biopsies helps to make an early and accurate clinically useful diagnosis in almost all of the normal looking or vesiculobullous or non neoplastic and neoplastic skin lesions, as the study of microscopic morphological features of different types of skin lesions had differentiating findings under the microscope.