HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC - DIODE ARRAY DETECTOR METHOD FOR SIMULTANEOUS ESTIMATION OF ESCITALOPRAM OXALATE AND FLUPENTIXOL DIHYDROCHLORIDE IN COMBINATION
Journal: Indian Drugs (Vol.56, No. 08)Publication Date: 2019-08-28
Authors : Gawande V. V.; Chandewar A. V.;
Page : 61-68
Keywords : * For Correspondence E-mail: viddya.gawande@rediffmail.com;
- HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC - DIODE ARRAY DETECTOR METHOD FOR SIMULTANEOUS ESTIMATION OF ESCITALOPRAM OXALATE AND FLUPENTIXOL DIHYDROCHLORIDE IN COMBINATION
- A NEW INVESTIGATIONAL METHOD FOR QUANTIFICATION AND VALIDATION OF ANALYTICAL METHOD FOR CEFIXIME AND ERDOSTEINE BY UPLC WITH PHOTO DIODE ARRAY DETECTOR IN BULK AND FORMULATION. APPLICATION TO THE ESTIMATION OF PRODUCT TRACES
- High Performance Liquid Chromatographic Method for Simultaneous Quantitation of Luteolin and Quercitin from Dried Whole Plant Powder of Gmelina Arborea Roxb.And Kalanchoe Pinnata (Lam.)Pers.
- DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF STRYCHNINE AND GALLIC ACID
- High Performance Liquid Chromatograph Method Development for the Simultaneous Estimation of Ibuprofen and Chlorpheniramine Maleate
Abstract
The proposed work involves High Performance Liquid Chromatographic – Diode Array Detector method for estimation of escitalopram oxalate and flupentixol dihydrochloride in combination. The analytes were resolved on Waters C18 Xterra column (50 × 4.6 mm id, particle size 3.5 μm) with mobile phase composition of water (containing 0.2 % triethylamine pH adjusted to 2.5 with orthophosphoric acid): acetonitrile: methanol (62:28:10 % v/v/v). The flow rate kept was 1.0 mL/min opting isocratic mode and eluents were tracked down at 230 nm. The retention times for both the drugs were 1.38±0.21 and 2.98±0.41, respectively. Standard addition method was employed for the analysis of flupentixol dihydrochloride. ICH guidelines were followed to validate the method. The method assured linearity in concentration range of 50-150 μg/mL and 2.5-7.5 μg/mL for ESC and FLU, respectively. The method assured high degree of precision and accuracy. The method was proved to be robust by assessing robustness parameters.
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