THE CURRENT STATUS OF ANTIBIOTIC SENSITIVITY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM VARIOUS CLINICAL SAMPLES

BACKGROUND: Pseudomonas aeruginosa has been emerged as an important pathogen and is one of the important causes of morbidity and mortality among hospital patients. Because of changing antibiotic sensitivity pattern, knowledge of current status of drug resistant is very important in clinical practice specifically in treatment of critically ill. MATERIALS AND METHODS: Total 2811 samples were tested during study period. All of them were subjected to direct microscopy and culture for identification & isolation of Ps. aeruginosa. Isolated colonies of Ps. aeruginosa were further subjected to antibiotic sensitivity testing for 12 routine antipseudomonal drugs. The isolates which are resistant to these drugs were further tested for 12 higher antibiotics. RESULTS: Pseudomonas aeruginosa were isolated from 228 (15.83%) samples. 53 (23.24%) isolates were resistant to the 12 routine anti-pseudomonal drugs. Out of 53 isolates, 16 (30.18%) isolates were resistant to all drugs tested. Maximum resistant isolates(9, 56.25%) were obtained from pus samples.CONCLUSION: It is evident from the study that nowadays Ps. aeruginosa is becoming less sensitive to cephalosporins, imipenem, aminoglycosides and β-lactamase inhibitors. To prevent the selection and spread of the resistant bacteria, it is critically important to have strict antibiotic policies.