Oral Administration of Menthol Alleviate Adverse Effects of Polycystic Ovarian Syndrome in Blood Biochemical Parameters and Antioxidant Status in Wister Rats

Background: Polycystic ovarian syndrome (PCOS) has been related to dyslipidemia and suppression of antioxidant status. Howeverl, novel agents such as menthol can be an efficient strategy for alleviation of PCOS. This study was conducted to evaluate the effects of different levels of menthol in blood biochemical parameters and antioxidant status in Wistar rats induced with PCOS. Methods: Fifty Wistar rats were used in this study and the animals divided into five groups including; 1) Control group (Control) or healthy rats, 2) PCOS group (PCOS) that did not receive any menthol, 3, 4 & 5) Animals that received 2, 4 and 6 mg/kg of body weight (PCOS-2, PCOS-4 and PCOS-6). To induce the PCOS, 5 mg estradiol valerate was administrated. At the end of the trial session, blood samples were taken to evaluate plasma concentrations of glucose, insulin, total cholesterol, triglycerides, HDL-C, LDL-C, ferric-reducing ability of plasma (FRAP), advanced oxidation protein product (AOPP) and total oxidation status (TOS). Results: Induction of PCOS increased glucose, insulin, total cholesterol, triglycerides, LDL-C, FRAP, AOPP and TOS, and decrease HDL-C. The use of menthol especially in higher levels improved the mentioned parameters. PCOS also increased body weight and oral treatment of menthol helped to maintain the body weight. Conclusion: It is concluded that menthol improved antioxidant status in rats with PCOS. Thus, use of menthol is recommended for treatment of PCOS.