EFFECT OF CAFFEINATED DRINK ON LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC MALE ALBINO RATS

Alteration of glucose metabolism has been shown to cause variation in the lipid profile. This study assesses the effects of caffeinated drink on lipid profile in the alloxan-induced diabetic male rat. We divided fifty male albino rats into five groups, Negative control, Positive (diabetes) control, and three experimental groups. The negative and positive controls were fed with standard rat chow with water, and the 3 test groups were fed with standard rat chow with water, and a relative percentage of caffeinated drink for two weeks. After two weeks of the experiments, the animals were sacrificed, and blood samples were collected, and laboratory investigations of serum lipid profile were carried out using the standard spectrophotometric method. Our result shows a significant increase (p < 0.05) in serum total- cholesterol (TC), Triglycerides (TG) and LDL-C but a significant decrease (p < 0.05) in serum HDL-C in the positive control group compared to the negative control. However, there was a noteworthy increase in Triglycerides (TG) and LDL-C in group 3 & 4 compared to the negative control. Also, there was a remarkable increase (p < 0.05) in serum HDL-C level in group 5 compared to negative control groups, while TC, TG & LDL-C serum level of group 5 are in equilibrium with the negative control group. Therefore, caffeinated drink can be said to have anti-lipidemic effect in the alloxan-induced diabetic male rats.