IN VITRO ANTIBACTERIAL ACTIVITY OF COMBRETUM RACEMOSUM P. BEAUV (COMBRETACEAE) ON METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS

The purpose of this study was to evaluate the in vitro antibacterial activity of Combretumracemosum on 3 clinical strains of Staphylococcus aureus (S. aureus 1987C / 18, S. aureus 1989C / 18 and S. aureus 1994C / 18) and a strain of reference (S. aureus ATCC 29213). The effect of aqueous total extract and hydro-ethanolic 70% extract of the plant on the growth of the strains was evaluated by determining the antimicrobial parameters by the method of wells in agar medium and by the method of microdilution in liquid medium. The aqueous total extract showed a better efficacy with a MIC ranging from 0.19 ? 0 mg / mL to 0.78 ? 0 mg / mL followed by hydro-ethanolic 70% extract with a MIC of 0, 39 ? 0 mg / mL at 1.56 ? 0 mg / mL. The BMCs of the extracts ranged from 0.39 ? 0 mg / mL to 1.56 ? 0 mg / mL (aqueous total extract) and from 1.56 ? 0 mg / mL to 3.12 ? 0 mg / mL (hydro-ethanolic 70% extract). Both extracts showed a bactericidal effect on all the strains tested. These results suggest that C. racemosum may be an alternative in the fight against Staphylococcus aureus infections.