Novel Diagnostic Biomarkers in Liver Disease-a Metabolomic Review | Biomed Grid

Disease of the liver are complex and pose significant challenges to physician due to diagnostic difficulty requiring invasive techniques such as liver biopsy. Changes in the odour of human excretions could provide diagnostic insight into pathophysiological imbalance. Identifying underlying volatiles metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odour. This has opened a promising area to lay the foundations of a rapid, non-invasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in liver disorders