SAFETY & EFFICACY OF MICRO NEEDLE ARRAY INSULIN PATCHES AND SUBCUTANEOUS ADMINISTRATION OF INSULIN: A COMPARATIVE ANALYSIS

Type I Diabetes mellitus (DM) patient's pancreas is not able to release sufficient amount of insulin. Insulin plays a key role in controlling blood glucose level. Generally, the primary outcome of Type I DM are to maintain the blood glucose levels in normal levels and prevention of Diabetic ketoacidosis (DKA) and the secondary outcome is to prevent organ damage like Diabetic retinopathy, Diabetic neuropathy, Diabetic nephropathy, etc. Currently, there are distinct forms of insulin's are available for subcutaneous (SC) administration. This includes Rapid-acting, Intermediate-acting, Long-acting, and Short-acting. For SC administration of insulin, there are different devices are available for administration of insulin, which includes insulin syringes, insulin infusion pumps, jet injectors, pens and insulin patches. The main objective of this study is to assess the safety and efficacy of SC administration insulin and Microneedle-array insulin patches (MNAIPs). In this study, we have conducted a systematic literature review of original articles and review articles. After reviewing we were found the several advantages of MNAIPs. Comparing the SC injections with MNAIPs having several advantages which include Good Safety and Efficacy, Good Bioavailability, Pain-free delivery, Minimal skin trauma and lack of bleeding. These advantages may enhance patient quality of life.