SYNTHESIS OF MANNICH BASES BASED ON NORBORNENYLMETHANOL, CYCLIC AMINES AND BENZALDEHYDE AND THEIR ANTIMICROBIAL ACTIVITY

On the basis of norbornenylmethanol, heterocyclic amines and benzaldehyde, new norbornene-containing Mannich bases were synthesized. The physico-chemical-characteristics of the target products were determined. The composition and structure of the synthesized compounds were confirmed by the methods of elemental analysis, IR spectroscopy, 1H and 13C NMR. The antimicrobial activity of the target products against various microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, Candida fungi) was studied, and the minimum inhibitory concentration and minimum bactericidal concentration of the studied compounds were determined with respect to some of the above microorganisms