Recent Advances in the Associations of Advanced Glycation End Products (Ages) and Cancer | Biomedgrid

Advanced glycation end products (AGEs) are reactive metabolites under physiological and pathological conditions. They accumulate in tissues and organs and are involved in the pathogenesis of various diseases including cancer. This review presents recent findings on the roles of AGEs and their receptor (RAGE) in carcinogenesis. The molecular mechanisms of cancer pathogenesis and progression related to AGEs-RAGE interaction are highlighted. The strategies for AGE reduction and inhibition in the potential prevention and treatment of cancers are discussed.