The Use of Ambrosia Moritima Methanolic Extract as Nephroprotective against Rifampin Induced Nephrotoxicity in Rats | Biomedgrid

Background and Objectives: Nephrotoxicity is a progressive loss in kidney function over a period of months or years. Rifampicin (RIF) is the first line drug for the treatment of tuberculosis and can cause nephrotoxicity in human beings and animals. Material and methods: Nephroprotective effect of methanolic extract of, Ambrosia moritima leaves was studied in healthy albino rats (1.25-1.75 kg) of either sex. This plant is a flowering plant in the family Asteraceae, they are distributed in the tropical and subtropical regions. It is used in traditional medicine for the treatment of renal failure, inflammation of kidney and other diseases. The renal toxicity was produced by administration of rifampin at dose rate of 70 mg/kg I/p for 28 days. The plant extract was given by simultaneous oral administration of methanolic extract of Ambrosia moritima leaves at a dose rate of 300 and 600mg/kg for 28 days. Results: It was found that the induced toxicity was inhibited by the administration of the extract. The decreased levels of serum urea, creatinine, sodium (Na) and potassium (K). Histopathological examination revealed protection of the kidney from the marked necrosis of renal tubules that induced by rifampin. Conclusion: Ambrosia moritima methanolic extract has a marked nephroprotective effect depending on the concentration