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THYROZINASE, ANTIOXIDANT, TOXICITY EVALUATION OF THE NOVEL BORON COMPOUND OBTAINED FROM 3-METHOXY CATECHOL AND 4-METHOXYPHENYLBORONIC ACID

Journal: Electronic Letters on Science & Engineering (Vol.14, No. 2)

Publication Date:

Authors : ;

Page : 33-34

Keywords : Thyozinase; antioxidant; toxicity; 4-methoxyphenylboronic acid;

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Abstract

Boron is an extremely valuable mineral and it is used in many products from cookware and medicine to nuclear waste storage and space exploration. Boron compounds are mainly used in borosilicate glass products, but are also used in agriculture, in fire retardants, and in soaps and detergents [1, 2]. In this study, new boron-derived compound synthesized by reacting 3-methoxy catechol compound with 4-methoxyphenylboronic acid and obtained compounds characterized by 1H, 13C NMR, UV-Vis., FTIR etc. Synthesis of ligand: 2 mmol (0.280 g) of 3-methoxy catechol was dissolved in 25 mL of THF. 1 mmol (0.152 g) of 4-methoxyphenylboronic acid was then dissolved in 10 mL of THF and added to the reflux flask. The reaction was maintained at 120 ° C for 4-5 hours. After heating, the solid substance in the solution was crystallized and washed in THF and dried. The cytotoxic activities of this new compound was evaluated by MTT method against 3 cell lines, antioxidant activities by ABTS cation radical decolorization method, cupric reducing antioxidant capacity assay and DPPH free radical scavenging activity methods. In addition, tyrosinase activities of this component was determined. As a result, the obtained new compound showed good degree activity in the three antioxidant activities. This compound is found to be more active than BHT and α-tocopherol in DPPH, ABTS and CUPRAC methods. The DPPH and ABTS methods of this compound was found to have IC50<1. In general, when looking at the cytotoxic and thyrozinase activities of this compound was found very low, despite this their antioxidant activities were found at high levels.

Last modified: 2019-11-13 18:42:49