Preliminary Study of Phytochemical Constituents and Acute Toxicity of Hibiscus Sabdariffa Extracts
Journal: International Journal of Trend in Scientific Research and Development (Vol.3, No. 6)Publication Date: 2019-11-02
Authors : Dada I. B. O. Bada S. O.;
Page : 997-1001
Keywords : Hibiscus sabdariffa; phtochemica; acute toxicity; haematology; biochemical;
Abstract
This study was done to assess the phytochemical constituents and acute toxicity of Hibiscus sabdariffa calyx and leaf extract. The crude extract of the plant parts were obtained after solvent percolation and drying. Then, the presence of tannins, saponin, flavonoids, alkaloids and phenol were assessed qualitatively. Also, albino rats Rattus norvegicus were used to assess the toxicity level of the plant materials, haematological and biochemical parameters of the test animal blood were also assessed. The results revealed that the two plant parts contained alkaloids, tannins, saponin, phenol and flavonoids. Also, In the acute toxicity assay, the oral lethal dose LD50 of 5000 mg kg bw and 2236.07 mg kg bw were recorded respectively for the calyx and leaf extract of the plant. The plant calyx and leaf extracts showed no significant p 0.05 effect on the levels of red blood cells RBC , white blood cells WBC , packed cell volume PCV , and haemoglobin concentration Hb albeit, the plant extracts had a significant increase effect on the platelet count of the rats. there was a significant increase in the alkaline phosphatase ALP , Alanine amino transaminase ALT and Aspartate amino transaminase AST in the group treated with the leaf extract compared with the control whereas the group treated with the calyx extract had comparable level of these enzymes with that of the control. These results has lent credence to the medicinal claim of the plant parts however, the leaf of the plant should be used in moderation. Dada, I. B. O. | Bada, S. O. "Preliminary Study of Phytochemical Constituents and Acute Toxicity of Hibiscus Sabdariffa Extracts" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29288.pdf Paper URL: https://www.ijtsrd.com/computer-science/other/29288/preliminary-study-of-phytochemical-constituents-and-acute-toxicity-of-hibiscus-sabdariffa-extracts/dada-i-b-o
Other Latest Articles
- Application of Vertex Colorings with Some Interesting Graphs
- Influence of Leadership Style and Employee Motivation toward Work Productivity of Employee Cooperation Operations PT. Angkasa Pura Solution with PT. Integreted Service Solutions KSO APS ISS
- Design and Construction of GSM Based Fire Alarm System using PIC Microcontroller
- Comparative Study of Free Radical Scavenging and Lipid Peroxidation Inhibition Potentials of Oxythenanthera Abyssinica Rhizomes Sourced from South Eastern Nigeria
- Architectural Education in Rural Areas - An Overview
Last modified: 2019-11-23 13:41:01