EVALUATION OF HYPOGLYCEMIC ACTIVITY OF PROSOPIS JULIFLORA ON ALLOXAN INDUCED DIABETIC RAT MODEL

The present study aimed to evaluate the hypoglycemic activity of Prosopis juliflora leaf extract on Alloxan-induced diabetic rats. Preliminary phytochemical investigation of P. juliflora leaf extract (PJLe) was done according to standard tests. the standardization of PJLe was done by HPTLC analysis. PJLe (100,200,400 mg/kg) was administered to all animals group-wise with standard glibenclamide, Normal saline solution for the normal control group for 21 days orally. After 21 days, one animal from each group were sacrificed. blood samples were collected for biochemical analysis and pancreas tissue was subjected to histopathological examination. Rats treated with PJLe showed significant changes in blood glucose level, body weight, organ weight and biochemical parameters. there was also a significant improvement in the histopathological scores in PJLe treated groups when compared with a diabetic control group. this study evaluates the effectiveness of PJLe as a therapeutic agent in hypoglycemic activity by alloxan-induced diabetic rat model in dose-dependent manner.