HEPATOPROTECTIVE ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR RATS
Journal: International Journal of Advanced Research (Vol.7, No. 10)Publication Date: 2019-10-02
Authors : Challa Pradeep kumar Penchala Prathap Munawwar Husain Kazmi B. Suhasini; Srujana thatipelly.;
Page : 318-322
Keywords : Hepatoprotective activity paracetamol Schisandra grandiflora hepatotoxicity silymarin.;
Abstract
Aim:Paracetamol (PCM) overdose induces Hepatotoxicity in humans and experimental animals. The present study aims to evaluate Hepatoprotective activity of Schisandra grandiflora against paracetamol induced hepatotoxicity. Method: In this experimental study wistar albino Rats were selected and Hepatotoxicity induced by paracetamol (PCM) p.o, 3g/kg body weight. On 7th day after the administration of plant extract and silymarin (50mg/kg) the plant extract of Schisandra grandiflora was administered orally at doses of 100mg/kg & 200mg/kg body weight daily for 7 days.Several serum makers, Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alkaline phasphatase (ALP), bilirubin total protein was measured to assess the effect of the extract on paracetamol Induced hepatic damage. A comparative histopathological study exhibited almost normal result as compared as control group.
Other Latest Articles
- Coronary angiographic profile in patients with failed thrombolysis
- ANTIMICROBIAL ACTIVITY OF INTESTINAL MICROORGANISMS DERIVED FROM PROTAETIA BREVITARSIS SEULENSIS LARVAE
- INDIVIDUAL TAXPAYER COMPLIANCE: MORAL ASPECT REVIEW IN TAXATION
- APPLICATION OF STRUCTURAL EQUATION MODELING (SEM) FOR ANALYSIS OF THE EFFECT OF PERCEPTION ON PROFESSIONALITY, KNOWLEDGE AND MOTIVATION OF NURSES ON THE IMPLEMENTATION OF PATIENTS SAFETY PROGRAMS IN THE INPATIENT ROOM OF RSUD X REGIONAL HOSPITAL SEMARANG
- IMPLEMENTATION OF SIX SIGMA APPROACH IN QUALITY CONTROL OF METAL CASTING PRODUCTS MADE FROM GRAY CAST IRON TYPE FC 250: A CASE STUDY IN SMALL AND MEDIUM ENTERPRISES IN INDONESIA
Last modified: 2019-11-28 18:07:47