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Kinetics and Mechanism of Oxidation of Omeprazole by Potassium Ferrate
Journal: International Journal of Medicine and Pharmaceutical Sciences (IJMPS) (Vol.9, No. 6)Publication Date: 2019-12-31
Authors : Vidyavati Shastry Ramyashree H; Ravindra K. S;
Page : 9-18
Keywords : Omeprazole; Potassium Ferrate & Oxidation;
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Abstract
The kinetics and mechanism of oxidation of Omeprazole [6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2- yl)methylsulfinyl]-1H-benzimidazole]by Potassium ferrate have been studied at 25°C. The stiochiometry has been observed to be 1:1 ratio of Fe(VI) ion and OMZ consumed. First order kinetics with respect to K2FeO4 was observed for the oxidation of OMZ. The effect of halide ions, ionic strength and dielectric constant has been studied on the rate of reaction. The reaction products were identified and characterized by LCMS. A suitable mechanism has been proposed on the basis of experimental results.
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Last modified: 2019-12-11 20:17:55