PROTECTIVE ROLES OF VITAMIN E TOWARD FORMALDEHYDE INDUCE DAMAGE IN FEMALE ALBINO MICE

The etiology of female infertility can be broken down into ovulation disorders uterine abnormalities, tubal obstruction, and peritoneal factors, cervical factors are also thought to play a minor role. Vitamin E is a fat-soluble antioxidant that stops the production of Reactive oxygen species (ROS) formed when fat undergoes oxidation; it may prevent or delay the chronic diseases associated with free radicals .The present study was designed to investigate the protective roles of antioxidants as vitamin E toward formaldehyde induce damage in female reproductive system. Female mice (n=50, 25-40 gm) were mated, every five female mice with one male mouse for 6 days for breeding. On the sixth day, female mice were divided into five groups: group 1 (control) administered tween 80 (5 ml/kg) for 5 days, group 2 received formaldehyde (30 mg/kg) for 5 days, group 3 received vitamin E (100mg/kg) for 5 days, group 4 administered formaldehyde and vitamin E (prophylactic) for 5 days, group 5 received formaldehyde for 5 days followed by vitamin E for another 5 days (curative). At the end of 21 days, animals were sacrificed; ovaries and uterus were removed and fixed in 10% formalin solution for routine histological techniques. Intraperitoneal administration was adopted in this study. Results: it was found that formaldehyde induced reproductive and developmental toxicities result in precipitous pathologies affecting female reproduction; Vitamin E is well accepted as nature's most effective lipid-soluble, chain-breaking antioxidant, protecting cell membranes from free- radical mediated per oxidative damage. It can be concluded that formaldehyde causes toxicity in female reproductive system. Vitamin E repair and treat formaldehyde toxicity. The improvement induced by vitamin E was more significant in treated group compared with prophylactic group