TROMBOPHILIA AS THE MAIN LINK OF PATHOGENESIS OF COMPLICATIONS IN OBSTETRICS AND GYNECOLOGY
Journal: Nauka i osvita / Science and Education (Vol.180, No. 3)Publication Date: 2019-12-27
Authors : Valery Linnikov Svyatoslav Linnikov;
Page : 31-36
Keywords : antiphospholipid syndrome; fetal loss syndrome; acquired and genetic thrombophilia; low-molecular weight heparin.;
Abstract
The analysis of gemostasiologikal researches on hidden got and genetic forms of trombophilia at women with the burdened anamnesis of syndrome of loss of a fetus. For certain established (p<0,05), that got thrombophilia, condi-tioned by the AFS at patients with FLS average - 28,6 % cases. The genetic mutation FVLeiden more frequent took place at patients with late abortions (14,3 %), the mutation of prothrombin gene G20210A met for certain rarer in all groups of reproduction losses - 4,8 %. The most widespread appeared the mutation МTHFR C677T - (45,2 %). Fac-tor of potential action of the AFA is genetic thrombophilia: AFS and MTHFR C677T at FLS in 17,4 %, AFS and FV Leiden at FLS at 9,6 %. Patogenetically grounded hidden got end genetic thrombophilia, syndrome of loss of fetus, thromboprophylaxis at these obstetric complications of LMWH - by сleхanе, begun with a fertile cycle and on the stage of invasion of throphoblasta, in absolute most cases (92 – 96 %) considerably improves the end of pregnancy.
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Last modified: 2019-12-27 20:07:28